KAIST successfully observed organoids in real-time using holographic tomography.

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, ‘KAIST (Korea Advanced Institute of Science and Technology) announced on the 14th that a research team led by Professor Park Yong-geun of the Department of Physics, in collaboration with the Genomic Correction Research Team of the Institute for Basic Science (IBS) and the medical device manufacturer Tomocube, has developed imaging technology that can observe living colon organoids in real-time at high resolution.’,
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, ‘Organoids are artificially created similar organs made by culturing human-derived cells, and they are used in experiments for toxicity and efficacy evaluation in the drug development stage.’,
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, ‘To understand the complex structure and dynamic biological phenomena of organoids, high-resolution real-time images are needed, but existing technologies require fluorescent staining for labeling, which takes a lot of time and poses problems.’,
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, ‘The research team successfully observed mouse colon organoids in real-time using holographic tomography technology, which allows for 3D biological sample analysis without any preprocessing.’,
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, ‘They quantitatively evaluated the growth patterns, morphological changes, protein density of the organoids, and successfully analyzed cell death and survival rates after drug treatment.’,
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, ‘The lead author of the paper, Dr. Lee Man-jae from KAIST, said, “This research with a new imaging technology that transcends existing limitations will contribute to disease modeling, personalized treatment, and drug development using organoids.”‘,
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, “The results of this research were published in the international journal ‘Experimental & Molecular Medicine’ online on the 1st of this month.”,
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