Written by • 2024-06-19• 11:21 AM• Tech

“The cause of severe neuropathic pain is excessive secretion of neural transmission materials.”

HomeTech“The cause of severe neuropathic pain is excessive secretion of neural transmission materials.”

Dr. Nam Min-ho of KIST “Identifying Core Mechanisms…Applicable to Diagnosis and Treatment”,
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, ‘(Seoul=Yonhap News) By Lee Ju-young = Domestic researchers have discovered that neuropathic pain, which causes severe pain even with mild stimuli, is due to the overproduction and secretion of the neurotransmitter GABA by non-neuronal reactive astrocytes in the spinal cord.’,
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New mechanism of neuropathic pain due to interaction between astrocytes and neurons In a neuropathic pain model, it was found that when reactive astrocytes overproduce the neurotransmitter GABA, the 'KCC2 transporter' protein responsible for transporting potassium ions (K+) and chloride ions (Cl-)` in nerve cells is reduced, leading to an increase in chloride ion concentration, resulting in excessive neuronal activation known as 'tonic excitation'. [Provided by Korea Institute of Science and Technology. Redistribution and reprinting prohibited]</em></span>, <br />, <br />, ‘The Korea Institute of Science and Technology (KIST) Brain Science Research Institute’s Dr. Nam Min-ho, in collaboration with Professor Kim Hyung-il’s team at the Gwangju Institute of Science and Technology (GIST), unveiled a new mechanism by which astrocytes trigger neuropathic pain and suggested personalized treatment and monitoring targets through this discovery.’, <br />, <br />, ‘Neuropathic pain is a condition where even minor stimuli result in excruciating pain as if being burned by fire, affecting the quality of life significantly and with a high prevalence rate, affecting one in ten individuals, but currently lacking a clear treatment method.’, <br />, <br />, ‘Neuropathic pain is known to be caused by ‘central sensitization’, where the transmission of pain signals in the spinal cord becomes overly sensitive, but the molecular-level causes have not been sufficiently elucidated, the research team explained.’, <br />, <br />, ‘Through neuropathic pain mouse model experiments, the research team revealed that reactive astrocytes in the spinal cord overproduce and secrete the neurotransmitter GABA, which typically acts to inhibit peripheral nerve cells.’, <br />, <br />, “When GABA is overproduced in astrocytes, it results in a decrease in the ‘KCC2 transporter’ protein responsible for transporting potassium ions (K+) and chloride ions (Cl-) in nerve cells, leading to an increase in chloride ion concentration and excessive neuronal activation causing neuropathic pain.”, <br />, <br />, “Furthermore, the research team successfully visualized the phenomenon of ‘tonic excitation’ in nerve cells due to overproduction of GABA in astrocytes using positron emission tomography (PET) with glucose labeled with a radioactive isotope.”, <br />, <br />, ‘<span class=

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‘, Therapeutic effect of neuropathic pain by monoamine oxidase B (MAOB) inhibitor Administering a drug that inhibits MAOB, the key enzyme that generates GABA in a neuropathic pain model mouse, inhibits the 'tonic excitation' of nerve cells within 2 weeks.

Therapeutic effect of neuropathic pain by monoamine oxidase B (MAOB) inhibitor
When administering a drug that inhibits MAOB, the key enzyme that generates GABA in a neuropathic pain model mouse, the ‘tonic excitation’ of nerve cells is inhibited within 2 weeks, as confirmed by positron emission tomography (PET) showing that glucose metabolism returns to normal levels (left). Also, mechanical allodynia measurements showed that administering MAOB inhibitors significantly restored pain thresholds in the neuropathic pain model within 1-2 weeks. [Provided by Korea Institute of Science and Technology. Redistribution and reprinting prohibited],
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, ‘Increased glucose metabolism was observed in the spinal cord of neuropathic pain model mice, and it was apparent that inhibiting monoamine oxidase B (MAOB), the key enzyme that generates GABA, restored spinal cord glucose metabolism to normal levels by preventing GABA production.’,
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, ‘The research team expects that positron emission tomography using glucose will visually display the progression of treatment, aiding in the prognosis management of neuropathic pain patients.’,
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, ‘Furthermore, clinical trials are planned not only for the application of MAOB inhibitors being used in ongoing treatments for diseases like Parkinson’s, but also for securing the therapeutic effects and safety of neuropathic pain treatment.’,
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, ‘Dr. Nam Min-ho stated, “Sustained excitation caused by GABA secretion in astrocytes is the cause of spinal cord neuronal hyperexcitability and the core mechanism of neuropathic pain,” adding, “These results will provide a crucial foundation for the development of new treatment strategies for neuropathic pain.”‘,
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, “This research result has been published in the latest issue of the international academic journal ‘Experimental & Molecular Medicine.'”,
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, ‘[email protected]’,
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